Mechanisms of Gene Regulation: How Science Works (Record no. 22709)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04964nam a22005295i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-3-030-52321-3 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20210415145206.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201029s2020 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783030523213 |
| -- | 978-3-030-52321-3 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-3-030-52321-3 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | R-RZ |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MBGR |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED000000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MBGR |
| Source | thema |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| Edition number | 23 |
| 037 ## - SOURCE OF ACQUISITION | |
| Source of stock number/acquisition | M/s. Indica Technologies & Services Pvt. Ltd., New Delhi – 110 002 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Carlberg, Carsten. |
| Relator term | author. |
| -- | (orcid)0000-0003-2633-0684 |
| -- | https://orcid.org/0000-0003-2633-0684 |
| Relator code | aut |
| -- | http://id.loc.gov/vocabulary/relators/aut |
| 245 10 - TITLE STATEMENT | |
| Title | Mechanisms of Gene Regulation: How Science Works |
| Medium | [electronic resource] / |
| Statement of responsibility, etc | by Carsten Carlberg, Ferdinand Molnár. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. 2020. |
| 264 #1 - | |
| -- | Cham : |
| -- | Springer International Publishing : |
| -- | Imprint: Springer, |
| -- | 2020. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | XVI, 149 p. 71 illus., 70 illus. in color. |
| Other physical details | online resource. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Central dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biochemistry. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Genetics. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine, general. |
| -- | https://scigraph.springernature.com/ontologies/product-market-codes/B0000X |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biochemistry, general. |
| -- | https://scigraph.springernature.com/ontologies/product-market-codes/L14005 |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Genetics and Genomics. |
| -- | https://scigraph.springernature.com/ontologies/product-market-codes/L32000 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Molnár, Ferdinand. |
| Relator term | author. |
| -- | (orcid)0000-0001-9008-4233 |
| -- | https://orcid.org/0000-0001-9008-4233 |
| Relator code | aut |
| -- | http://id.loc.gov/vocabulary/relators/aut |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer Nature eBook |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9783030523206 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9783030523220 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1007/978-3-030-52321-3">https://doi.org/10.1007/978-3-030-52321-3</a> |
| 912 ## - | |
| -- | ZDB-2-SBL |
| 912 ## - | |
| -- | ZDB-2-SXB |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | EBooks |
No items available.